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Hyperuricemia, Gout, and the Brain-an Update.
Latourte, Augustin; Dumurgier, Julien; Paquet, Claire; Richette, Pascal.
Afiliação
  • Latourte A; Université de Paris, INSERM, UMR-S, 1132 BIOSCAR, 75010, Paris, France. augustin.latourte@aphp.fr.
  • Dumurgier J; Rheumatology Department, AP-HP, Lariboisière Hospital, 2 rue Ambroise Paré, 75010, Paris, France. augustin.latourte@aphp.fr.
  • Paquet C; Cognitive Neurology Centre, GHU Nord APHP Lariboisière Fernand-Widal Hospital, Paris, France.
  • Richette P; Cognitive Neurology Centre, GHU Nord APHP Lariboisière Fernand-Widal Hospital, Paris, France.
Curr Rheumatol Rep ; 23(12): 82, 2021 12 30.
Article em En | MEDLINE | ID: mdl-34971414
ABSTRACT
PURPOSE OF REVIEW This review aims to summarize recent evidence regarding the complex relationship between uric acid (UA), gout, and brain diseases. RECENT

FINDINGS:

Observational studies have suggested that patients with hyperuricemia or gout might have a decreased risk of neurodegenerative diseases. Conversely, they may be at increased risk of cerebrovascular disease. Mendelian randomization (MR) studies use a genetic score as an instrumental variable to address the causality of the association between a risk factor (here, UA or gout) and an outcome. So far, MR analyses do not support a causal relationship of UA or gout with Alzheimer's disease and dementia, and of UA with Parkinson's disease or stroke. Observation studies indicate a U-shaped association between UA and brain diseases, but MR studies do not support that this association is causal. Further studies should address the causal role of gout as well as the impact of urate-lowering therapy on these outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperuricemia / Gota Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperuricemia / Gota Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article