Tumor necrosis factor &#945; upregulates the bile acid efflux transporter OATP3A1 via multiple signaling pathways in cholestasis.

Li, Mingqiao; Wang, Weihua; Cheng, Ying; Zhang, Xiaoxun; Zhao, Nan; Tan, Ya; Xie, Qiaoling; Chai, Jin; Pan, Qiong

Tumor necrosis factor α upregulates the bile acid efflux transporter OATP3A1 via multiple signaling pathways in cholestasis.

Li, Mingqiao; Wang, Weihua; Cheng, Ying; Zhang, Xiaoxun; Zhao, Nan; Tan, Ya; Xie, Qiaoling; Chai, Jin; Pan, Qiong.

Afiliação

Li M; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Wang W; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Cheng Y; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Zhang X; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Zhao N; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Tan Y; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Xie Q; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Chai J; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address: jin.chai@cldcsw.org.
Pan Q; Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address: qiong.pan@cldcsw.org.

J Biol Chem ; 298(2): 101543, 2022 02.

Article em En | MEDLINE | ID: mdl-34971708

Assuntos

Colestase; Transportadores de Ânions Orgânicos; Fator de Necrose Tumoral alfa; Ácidos e Sais Biliares/metabolismo; Colestase/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Humanos; NF-kappa B/metabolismo; Transportadores de Ânions Orgânicos/metabolismo; RNA Mensageiro/metabolismo; Transdução de Sinais; Fator de Necrose Tumoral alfa/metabolismo; Regulação para Cima

Palavras-chave

NF-κB; OATP3A1; SP1; TNFα; cholestasis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colestase / Fator de Necrose Tumoral alfa / Transportadores de Ânions Orgânicos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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