Nur77 ameliorates age-related renal tubulointerstitial fibrosis by suppressing the TGF-ß/Smads signaling pathway.

Ma, Guojing; Chen, Feng; Liu, Yixuan; Zheng, Lixia; Jiang, Xuehan; Tian, Huanlian; Wang, Xiaoxun; Song, Xiaoyu; Yu, Yang; Wang, Difei

Ma, Guojing; Chen, Feng; Liu, Yixuan; Zheng, Lixia; Jiang, Xuehan; Tian, Huanlian; Wang, Xiaoxun; Song, Xiaoyu; Yu, Yang; Wang, Difei.

Afiliação

Ma G; Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Chen F; Key Laboratory of Medical Cell Biology, Institute of Translational Medicine, China Medical University, Shenyang, China.
Liu Y; Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Zheng L; Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Jiang X; Key Laboratory of Medical Cell Biology, Institute of Translational Medicine, China Medical University, Shenyang, China.
Tian H; Institute of Health Sciences, China Medical University, Shenyang, China.
Wang X; Key Laboratory of Medical Cell Biology, Institute of Translational Medicine, China Medical University, Shenyang, China.
Song X; Institute of Health Sciences, China Medical University, Shenyang, China.
Yu Y; Department of Health Statistics, School of Public Health, China Medical University, Shenyang, China.
Wang D; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, China.

FASEB J ; 36(2): e22124, 2022 02.

Article em En | MEDLINE | ID: mdl-34972249

Assuntos

Envelhecimento/metabolismo; Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares/metabolismo; Insuficiência Renal Crônica/metabolismo; Transdução de Sinais; Proteínas Smad/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Envelhecimento/genética; Animais; Fibrose; Camundongos; Camundongos Knockout; Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares/genética; Insuficiência Renal Crônica/genética; Proteínas Smad/genética; Fator de Crescimento Transformador beta/genética

Palavras-chave

Nur77; Smad7; TGF-ß/Smads signaling pathway; aging; renal fibrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Transdução de Sinais / Fator de Crescimento Transformador beta / Insuficiência Renal Crônica / Proteínas Smad / Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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