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Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Dixit, Deobrat; Prager, Briana C; Gimple, Ryan C; Miller, Tyler E; Wu, Qiulian; Yomtoubian, Shira; Kidwell, Reilly L; Lv, Deguan; Zhao, Linjie; Qiu, Zhixin; Zhang, Guoxin; Lee, Derrick; Park, Donglim Esther; Wechsler-Reya, Robert J; Wang, Xiuxing; Bao, Shideng; Rich, Jeremy N.
Afiliação
  • Dixit D; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Prager BC; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Gimple RC; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Miller TE; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44106, USA.
  • Wu Q; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Yomtoubian S; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Kidwell RL; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Lv D; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Zhao L; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA.
  • Qiu Z; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Zhang G; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Lee D; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Park DE; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA.
  • Wechsler-Reya RJ; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Wang X; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA.
  • Bao S; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  • Rich JN; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Sci Transl Med ; 14(626): eabf3917, 2022 01 05.
Article em En | MEDLINE | ID: mdl-34985972
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Glioblastoma / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Glioblastoma / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article