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Chemoproteomic Analysis of Microbiota Metabolite-Protein Targets and Mechanisms.
Zhao, Xiaohui; Yang, Xinglin; Hang, Howard C.
Afiliação
  • Zhao X; Department of Immunology and Microbiology and Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.
  • Yang X; Department of Immunology and Microbiology and Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.
  • Hang HC; Department of Immunology and Microbiology and Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.
Biochemistry ; 61(24): 2822-2834, 2022 12 20.
Article em En | MEDLINE | ID: mdl-34989554
The microbiota have emerged as an important factor in host physiology, disease, and response to therapy. These diverse microbes (bacteria, virus, fungi, and protists) encode unique functions and metabolites that regulate intraspecies and interspecies interactions. While the mechanisms of some microbiota species and metabolites have been elucidated, the diversity and abundance of different microbiota species and their associated pathways suggest many more metabolites and mechanisms of action remain to be discovered. In this Perspective, we highlight how the advances in chemical proteomics have provided new opportunities to elucidate the molecular targets of specific microbiota metabolites and reveal new mechanisms of action. The continued development of specific microbiota metabolite reporters and more precise proteomic methods should reveal new microbiota mechanisms of action, therapeutic targets, and biomarkers for a variety of human diseases.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / Microbiota Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / Microbiota Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article