A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aß-induced toxicity in C. elegans.
Chem Commun (Camb)
; 58(10): 1514-1517, 2022 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-34994366
ABSTRACT
A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aß-induced toxicity in the Caenorhabditis elegans model, which has never been reported.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paládio
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Caenorhabditis elegans
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Substâncias Protetoras
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Complexos de Coordenação
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Gliclazida
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article