Association of HMOX-1 rs2071747 with sporadic Parkinson's disease in southern Han Chinese.
Neurol Sci
; 43(6): 3671-3675, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-35006443
ABSTRACT
STUDY OBJECTIVES:
To discover the associations between HMOX-1 and sporadic Parkinson's disease (PD).METHODS:
Five hundred sporadic PD patients and 500 healthy controls were recruited in this study. Polymerase chain reaction (PCR) was used.RESULTS:
The dominant model of HMOX-1 rs2071747 was shown statistically significant between PD patients and control after adjustment of age and gender (dominant model p value 0.045, OR 1.51, 95% CI 1.01-2.27, adjusted). The associations of additive model and dominant model of rs2071747 were also found (additive model p value 0.047; dominant model p value 0.035, OR 1.55, 95% CI 1.03, 2.34).CONCLUSIONS:
We found the association of the dominant of HMOX1 rs2071747 with PD. We also found the associations of additive model and dominant model of HMOX1 rs2071747 with late onset PD (LOPD) patients. HIGHLIGHTS ⢠The dominant model of HMOX1 rs2071747 was associated with PD. ⢠The additive model of HMOX1 rs2071747 was associated with LOPD. ⢠The dominant model of HMOX1 rs2071747 was associated with LOPD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Predisposição Genética para Doença
/
Heme Oxigenase-1
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article