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Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.
Nagatake, Takahiro; Kishino, Shigenobu; Urano, Emiko; Murakami, Haruka; Kitamura, Nahoko; Konishi, Kana; Ohno, Harumi; Tiwari, Prabha; Morimoto, Sakiko; Node, Eri; Adachi, Jun; Abe, Yuichi; Isoyama, Junko; Sawane, Kento; Honda, Tetsuya; Inoue, Asuka; Uwamizu, Akiharu; Matsuzaka, Takashi; Miyamoto, Yoichi; Hirata, So-Ichiro; Saika, Azusa; Shibata, Yuki; Hosomi, Koji; Matsunaga, Ayu; Shimano, Hitoshi; Arita, Makoto; Aoki, Junken; Oka, Masahiro; Matsutani, Akira; Tomonaga, Takeshi; Kabashima, Kenji; Miyachi, Motohiko; Yasutomi, Yasuhiro; Ogawa, Jun; Kunisawa, Jun.
Afiliação
  • Nagatake T; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Kishino S; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan.
  • Urano E; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, NIBIOHN, 1-1 Hachimandai, Tsukuba, Ibaraki, 305-0843, Japan.
  • Murakami H; Department of Physical Activity Research, NIBIOHN, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan.
  • Kitamura N; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan.
  • Konishi K; Department of Physical Activity Research, NIBIOHN, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan.
  • Ohno H; Department of Physical Activity Research, NIBIOHN, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan.
  • Tiwari P; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Morimoto S; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Node E; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Adachi J; Laboratory of Proteome Research and Laboratory of Proteomics for Drug Discovery, NIBIOHN, 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Abe Y; Laboratory of Proteome Research and Laboratory of Proteomics for Drug Discovery, NIBIOHN, 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Isoyama J; Division of Molecular Diagnostics, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
  • Sawane K; Laboratory of Proteome Research and Laboratory of Proteomics for Drug Discovery, NIBIOHN, 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Honda T; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Inoue A; Graduate School of Pharmaceutical Sciences, Osaka University, 1-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Uwamizu A; Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawara-cho, Kyoto, 606-8507, Japan.
  • Matsuzaka T; Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
  • Miyamoto Y; Department of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
  • Hirata SI; Department of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
  • Saika A; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Shibata Y; Department of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Hosomi K; Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Matsunaga A; Laboratory of Nuclear Transport Dynamics, NIBIOHN, 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Shimano H; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Arita M; Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
  • Aoki J; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Oka M; Graduate School of Pharmaceutical Sciences, Osaka University, 1-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Matsutani A; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Tomonaga T; Graduate School of Pharmaceutical Sciences, Osaka University, 1-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Kabashima K; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Miyachi M; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan.
  • Yasutomi Y; Faculty of Agriculture, Takasaki University of Health and Welfare, 54 Nakaoruimachi, Takasaki, Gumma, 370-0033, Japan.
  • Ogawa J; Department of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Kunisawa J; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, 1-5-30 Shibakouen, Minato-ku, Tokyo, 105-8512, Japan.
Mucosal Immunol ; 15(2): 289-300, 2022 02.
Article em En | MEDLINE | ID: mdl-35013573
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta Hiperlipídica / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta Hiperlipídica / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article