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Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait.
Venkataraman, Thiagarajan; Valencia, Cristian; Mangino, Massimo; Morgenlander, William; Clipman, Steven J; Liechti, Thomas; Valencia, Ana; Christofidou, Paraskevi; Spector, Tim; Roederer, Mario; Duggal, Priya; Larman, H Benjamin.
Afiliação
  • Venkataraman T; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
  • Valencia C; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Mangino M; Department of Twin Research & Genetic Epidemiology, King's College of London, London, UK; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London SE1 9RT, UK.
  • Morgenlander W; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
  • Clipman SJ; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Liechti T; ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
  • Valencia A; School of Medicine, Universidad Pontificia Bolivariana, Medellín, Colombia.
  • Christofidou P; Department of Twin Research & Genetic Epidemiology, King's College of London, London, UK.
  • Spector T; Department of Twin Research & Genetic Epidemiology, King's College of London, London, UK.
  • Roederer M; ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
  • Duggal P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Larman HB; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: hlarman1@jhu.edu.
Immunity ; 55(1): 174-184.e5, 2022 01 11.
Article em En | MEDLINE | ID: mdl-35021055
ABSTRACT
Human immune responses to viral infections are highly variable, but the genetic factors that contribute to this variability are not well characterized. We used VirScan, a high-throughput epitope scanning technology, to analyze pan-viral antibody reactivity profiles of twins and SNP-genotyped individuals. Using these data, we determined the heritability and genomic loci associated with antibody epitope selection, response breadth, and control of Epstein-Barr virus (EBV) viral load. 107 EBV peptide reactivities were heritable and at least two Epstein-Barr nuclear antigen 2 (EBNA-2) reactivities were associated with variants in the MHC class II locus. We identified an EBV serosignature that predicted viral load in peripheral blood mononuclear cells and was associated with variants in the MHC class I locus. Our study illustrates the utility of epitope profiling to investigate the genetics of pathogen immunity, reports heritable features of the antibody response to viruses, and identifies specific HLA loci important for EBV epitope selection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Epitopos Imunodominantes / Herpesvirus Humano 4 / Antígenos Nucleares do Vírus Epstein-Barr / Infecções por Vírus Epstein-Barr / Genótipo / Anticorpos Antivirais / Epitopos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Epitopos Imunodominantes / Herpesvirus Humano 4 / Antígenos Nucleares do Vírus Epstein-Barr / Infecções por Vírus Epstein-Barr / Genótipo / Anticorpos Antivirais / Epitopos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article