6-MAM, 6-Monoacetylmorphine; AMPH, amphetamines/ecstasy; BENZ, benzodiazepines; BUPR, buprenorphine; CE, Collision energy; COV, compensation voltage; CXP, collision cell exit potential; DAPPI, atmospheric pressure photo ionization; DART, direct analysis in real time; DC, direct current; DESI, desorption electrospray ionization; DMO, DMS offse; DMS, differential mobility separation; DP, declustering potential; DR, DMS resolution enhancement; DT, DMS cell temperature; Differential mobility separation; Drugs of abuse; EDDP, 2-ethylidene1,5-dimethyl-3,3-diphenylpyrrolidine; EP, entrance potential; FAIMS, field asymmetric waveform ion mobility spectrometry; FSI, fiber spray ionization; GC-MS or LC-MS, gas chromatography- or liquid chromatography-mass spectrometry; GS1, ion source gas 1; GS2, ion source gas 2; IMS, ion mobility spectrometry, IS, internal standards, LOD, limit of detection, MD, modifier, MDC, modifier composition, ME, matrix effects; MRM, multiple reaction monitoring; MS/MS, tandem mass spectrometry; Mass spectrometry; OPI, opiates; OXY, oxycodone/oxmorphone; QCs, quality controls; SRM, selected reaction monitoring; SV, separation voltage; Urine drug screening; WT-ESI, wooden-tip electrospray ionization