Abiraterone switches castration-resistant prostate cancer dependency from adrenal androgens towards androgen receptor variants and glucocorticoid receptor signalling.

Moll, J Matthijs; Hofland, Johannes; Teubel, Wilma J; de Ridder, Corina M A; Taylor, Angela E; Graeser, Ralph; Arlt, Wiebke; Jenster, Guido W; van Weerden, Wytske M

Moll, J Matthijs; Hofland, Johannes; Teubel, Wilma J; de Ridder, Corina M A; Taylor, Angela E; Graeser, Ralph; Arlt, Wiebke; Jenster, Guido W; van Weerden, Wytske M.

Afiliação

Moll JM; Department of Urology, Erasmus MC, Rotterdam, The Netherlands.
Hofland J; Department of Endocrinology, Erasmus MC, Rotterdam, The Netherlands.
Teubel WJ; Centre for Endocrinology, Diabetes and Metabolism (CEDAM), School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
de Ridder CMA; Department of Urology, Erasmus MC, Rotterdam, The Netherlands.
Taylor AE; Department of Urology, Erasmus MC, Rotterdam, The Netherlands.
Graeser R; Centre for Endocrinology, Diabetes and Metabolism (CEDAM), School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
Arlt W; Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA.
Jenster GW; Centre for Endocrinology, Diabetes and Metabolism (CEDAM), School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
van Weerden WM; Department of Urology, Erasmus MC, Rotterdam, The Netherlands.

Prostate ; 82(5): 505-516, 2022 04.

Article em En | MEDLINE | ID: mdl-35037287

Assuntos

Androgênios; Neoplasias de Próstata Resistentes à Castração; Androgênios/metabolismo; Androstenos/farmacologia; Androstenos/uso terapêutico; Animais; Linhagem Celular Tumoral; Humanos; Ligantes; Masculino; Camundongos; Nitrilas/uso terapêutico; Orquiectomia; Antígeno Prostático Específico; Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico; Neoplasias de Próstata Resistentes à Castração/genética; Neoplasias de Próstata Resistentes à Castração/metabolismo; Receptores Androgênicos/genética; Receptores Androgênicos/metabolismo; Receptores de Glucocorticoides

Palavras-chave

AR variants; CYP17A1 inhibition; abiraterone; adrenal androgens; androgen synthesis; castration resistant prostate cancer; glucocorticoid receptor; xenograft

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração / Androgênios Tipo de estudo: Clinical_trials Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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