The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.
Nat Genet
; 54(2): 121-124, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-35039640
Using online surveys, we collected data regarding COVID-19-related loss of smell or taste from 69,841 individuals. We performed a multi-ancestry genome-wide association study and identified a genome-wide significant locus in the vicinity of the UGT2A1 and UGT2A2 genes. Both genes are expressed in the olfactory epithelium and play a role in metabolizing odorants. These findings provide a genetic link to the biological mechanisms underlying COVID-19-related loss of smell or taste.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glucuronosiltransferase
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Ageusia
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Estudo de Associação Genômica Ampla
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Loci Gênicos
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Anosmia
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COVID-19
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UDP-Glucuronosiltransferase 1A
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article