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Cell-penetrating poly(disulfide)-based nanoquenchers (qCPDs) for self-monitoring of intracellular gene delivery.
Lang, Wenjie; Liew, Si Si; Wang, Shuyi; Hong, Dawei; Zhu, Liquan; Du, Shubo; Jiang, Linye; Yao, Shao Q; Ge, Jingyan.
Afiliação
  • Lang W; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. gejy@zjut.edu.cn.
  • Liew SS; Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Singapore. chmyaosq@nus.edu.sg.
  • Wang S; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. gejy@zjut.edu.cn.
  • Hong D; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. gejy@zjut.edu.cn.
  • Zhu L; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. gejy@zjut.edu.cn.
  • Du S; Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Singapore. chmyaosq@nus.edu.sg.
  • Jiang L; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. gejy@zjut.edu.cn.
  • Yao SQ; Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Singapore. chmyaosq@nus.edu.sg.
  • Ge J; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. gejy@zjut.edu.cn.
Chem Commun (Camb) ; 58(11): 1792-1795, 2022 Feb 03.
Article em En | MEDLINE | ID: mdl-35040443
ABSTRACT
Monitoring gene delivery has significant benefits in gene therapy. Herein, we report a nanoquencher system by doping a FRET pair during nucleic acid-assisted cell penetrating poly(disulfide) (CPD) formation. Our results show that this strategy not only produces an efficient gene delivery polymer with minimal endolysosomal trapping, but also enables monitoring the release of the gene from the vehicle in live cells. This study further expanded the application of CPDs as promising tools in gene delivery.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dissulfetos Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dissulfetos Idioma: En Ano de publicação: 2022 Tipo de documento: Article