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Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants.
Zhang, Lianghui; Dutta, Soumajit; Xiong, Shiqin; Chan, Matthew; Chan, Kui K; Fan, Timothy M; Bailey, Keith L; Lindeblad, Matthew; Cooper, Laura M; Rong, Lijun; Gugliuzza, Anthony F; Shukla, Diwakar; Procko, Erik; Rehman, Jalees; Malik, Asrar B.
Afiliação
  • Zhang L; Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA. lhzhang@uic.edu.
  • Dutta S; Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL, USA.
  • Xiong S; Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA.
  • Chan M; Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL, USA.
  • Chan KK; Cyrus Biotechnology, Inc., Seattle, WA, USA.
  • Fan TM; Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL, USA.
  • Bailey KL; Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL, USA.
  • Lindeblad M; Toxicology Research Laboratory, Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
  • Cooper LM; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA.
  • Rong L; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA.
  • Gugliuzza AF; Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA.
  • Shukla D; Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL, USA.
  • Procko E; Department of Biochemistry, University of Illinois, Urbana, IL, USA. procko@illinois.edu.
  • Rehman J; Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA. jalees@uic.edu.
  • Malik AB; Division of Cardiology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL, USA. jalees@uic.edu.
Nat Chem Biol ; 18(3): 342-351, 2022 03.
Article em En | MEDLINE | ID: mdl-35046611
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article