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Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study.
Congiu, T; Fanni, D; Piras, M; Gerosa, C; Cau, F; Barcellona, D; D'Aloja, E; Demontis, R; Chighine, A; Nioi, M; Coni, P; Ravarino, A; Cerrone, G; Aimola, V; Botta, C; Scano, A; Orrù, G; Coghe, F; Van Eyken, P; La Nasa, G; Saba, L; Suri, J S; Faa, G; Marongiu, F.
Afiliação
  • Congiu T; Division of Pathology, Department of Medical Sciences and Public Health, AOU of Cagliari, University of Cagliari, Cagliari, Italy. daniela.fanni@unica.it.
Eur Rev Med Pharmacol Sci ; 26(1): 270-277, 2022 01.
Article em En | MEDLINE | ID: mdl-35049004
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare new syndrome occurring after the ChAdOx1 nCoV-19 vaccine immunization. Patients with VITT are characterized by a variable clinical presentation, likewise also the outcome of these patients is very variable. Here we report the lung ultrastructural findings in the course of VITT of a 58-year-old male patient. Alveoli were mainly dilated, irregular in shape, and occupied by a reticular network of fibrin, while interalveolar septa appeared thickened. The proliferation of small capillaries gave rise to plexiform structures and pulmonary capillary hemangiomatosis-like features. Near the alveoli occupied by a dense fibrin network, the medium-sized arteries showed a modified wall and an intraluminal thrombus. This scenario looks quite similar to that found during COVID-19, where the lungs suffer from the attack of the antigen-antibodies complexes and the virus respectively. In both diseases, the final outcome is a severe inflammation, activation of the haemostatic system and fibrinolysis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinação / Púrpura Trombocitopênica Idiopática / Lesão Pulmonar / ChAdOx1 nCoV-19 Tipo de estudo: Diagnostic_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinação / Púrpura Trombocitopênica Idiopática / Lesão Pulmonar / ChAdOx1 nCoV-19 Tipo de estudo: Diagnostic_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article