Identification of a Novel Oncogenic Fusion Gene <i>SPON1-TRIM29</i> in Clinical Ovarian Cancer That Promotes Cell and Tumor Growth and Enhances Chemoresistance in A2780 Cells.

Nagasawa, Saya; Ikeda, Kazuhiro; Shintani, Daisuke; Yang, Chiujung; Takeda, Satoru; Hasegawa, Kosei; Horie, Kuniko; Inoue, Satoshi

Identification of a Novel Oncogenic Fusion Gene SPON1-TRIM29 in Clinical Ovarian Cancer That Promotes Cell and Tumor Growth and Enhances Chemoresistance in A2780 Cells.

Nagasawa, Saya; Ikeda, Kazuhiro; Shintani, Daisuke; Yang, Chiujung; Takeda, Satoru; Hasegawa, Kosei; Horie, Kuniko; Inoue, Satoshi.

Afiliação

Nagasawa S; Division of Systems Medicine & Gene Therapy, Saitama Medical University, Hidaka 350-1241, Saitama, Japan.
Ikeda K; Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Shintani D; Division of Systems Medicine & Gene Therapy, Saitama Medical University, Hidaka 350-1241, Saitama, Japan.
Yang C; Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka 350-1298, Saitama, Japan.
Takeda S; Division of Systems Medicine & Gene Therapy, Saitama Medical University, Hidaka 350-1241, Saitama, Japan.
Hasegawa K; Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Horie K; Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Inoue S; Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka 350-1298, Saitama, Japan.

Int J Mol Sci ; 23(2)2022 Jan 08.

Article em En | MEDLINE | ID: mdl-35054873

Assuntos

Resistencia a Medicamentos Antineoplásicos/genética; Proteínas de Fusão Oncogênica; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/patologia; Animais; Apoptose/genética; Sequência de Bases; Linhagem Celular Tumoral; Proliferação de Células/genética; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Camundongos Endogâmicos BALB C; Camundongos Nus; Neoplasias Ovarianas/tratamento farmacológico; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

Palavras-chave

RNA-sequencing; fusion transcript; ovarian cancer; small interfering RNA (siRNA); xenograft

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Proteínas de Fusão Oncogênica / Resistencia a Medicamentos Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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