Genome-Wide CRISPR/Cas9-Based Screening for Deubiquitinase Subfamily Identifies Ubiquitin-Specific Protease 11 as a Novel Regulator of Osteogenic Differentiation.

Kaushal, Kamini; Tyagi, Apoorvi; Karapurkar, Janardhan Keshav; Kim, Eun-Jung; Tanguturi, Parthasaradhireddy; Kim, Kye-Seong; Jung, Han-Sung; Ramakrishna, Suresh

Kaushal, Kamini; Tyagi, Apoorvi; Karapurkar, Janardhan Keshav; Kim, Eun-Jung; Tanguturi, Parthasaradhireddy; Kim, Kye-Seong; Jung, Han-Sung; Ramakrishna, Suresh.

Afiliação

Kaushal K; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Tyagi A; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Karapurkar JK; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Kim EJ; Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Korea.
Tanguturi P; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Kim KS; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Jung HS; College of Medicine, Hanyang University, Seoul 04763, Korea.
Ramakrishna S; Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Korea.

Int J Mol Sci ; 23(2)2022 Jan 13.

Article em En | MEDLINE | ID: mdl-35055037

Assuntos

Sistemas CRISPR-Cas; Diferenciação Celular/genética; Enzimas Desubiquitinantes/genética; Estudo de Associação Genômica Ampla/métodos; Osteogênese/genética; Tioléster Hidrolases/genética; Enzimas Desubiquitinantes/metabolismo; Regulação da Expressão Gênica; Humanos; Fator de Transcrição MSX1/genética; Fator de Transcrição MSX1/metabolismo; Células-Tronco Mesenquimais/citologia; Células-Tronco Mesenquimais/metabolismo; Proteólise; Medicina Regenerativa; Tioléster Hidrolases/metabolismo; Fatores de Transcrição/metabolismo; Ubiquitinação

Palavras-chave

protein degradation; regenerative medicine; stem cells; ubiquitination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Tioléster Hidrolases / Diferenciação Celular / Estudo de Associação Genômica Ampla / Sistemas CRISPR-Cas / Enzimas Desubiquitinantes Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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