Acute exposure to gold nanoparticles aggravates lipopolysaccharide-induced liver injury by amplifying apoptosis via ROS-mediated macrophage-hepatocyte crosstalk.

Yang, Yongjun; Fan, Shijun; Chen, Qian; Lu, Yongling; Zhu, Yuanfeng; Chen, Xiaoli; Xia, Lin; Huang, Qianying; Zheng, Jiang; Liu, Xin

Yang, Yongjun; Fan, Shijun; Chen, Qian; Lu, Yongling; Zhu, Yuanfeng; Chen, Xiaoli; Xia, Lin; Huang, Qianying; Zheng, Jiang; Liu, Xin.

Afiliação

Yang Y; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Fan S; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Chen Q; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Lu Y; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Zhu Y; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Chen X; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Xia L; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Huang Q; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Zheng J; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China.
Liu X; Medical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, 400038, China. liux0704@tmmu.edu.cn.

J Nanobiotechnology ; 20(1): 37, 2022 Jan 20.

Article em En | MEDLINE | ID: mdl-35057820

Assuntos

Doença Hepática Crônica Induzida por Substâncias e Drogas/patologia; Ouro/toxicidade; Hepatócitos; Lipopolissacarídeos/efeitos adversos; Nanopartículas Metálicas/toxicidade; Animais; Apoptose/efeitos dos fármacos; Comunicação Celular/efeitos dos fármacos; Células HEK293; Hepatócitos/efeitos dos fármacos; Hepatócitos/metabolismo; Humanos; Fígado/efeitos dos fármacos; Fígado/patologia; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Espécies Reativas de Oxigênio/metabolismo; Testes de Toxicidade Aguda

Palavras-chave

Acute liver injury; Apoptosis; AuNPs; Lipopolysaccharide; Reactive oxygen species

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Hepatócitos / Nanopartículas Metálicas / Doença Hepática Crônica Induzida por Substâncias e Drogas / Ouro Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google