POTENTIAL ROLE OF VITAMIN D3 IN AMELIORATING DOXORUBICIN INDUCED CARDIOTOXICITY IN MALE RATS.

ABSTRACT

OBJECTIVE: The aim: The goal of this study was to asses if vitamin D3 protect rats against doxorubicin-induced cardiotoxicity. PATIENTS AND METHODS: Materials and methods: Overall twenty-one male rats were divided randomly into three groups (7 rats in each group). Control group in which rats received 0.9% normal saline for two weeks. Doxorubicin group (induced group) rats received 2.5mg/kg three times a week for two weeks and Vitamin D3 group (treated group) vitamin D3 was given in a dose 60000 IU/kg IP as single dose on the first day of the procedure. RESULTS: Results: Doxorubicin caused cardiotoxicity as indicated by a significant elevation (P < 0.01) in TNF-α, IL-6, MDA, cTnI and caspase-3 level, while TAC and Bcl-2 levels significantly (P < 0.01) reduced in cardiac tissues of rats in the doxorubicin group as compared with control group, also doxorubicin caused histological lesions. Vitamin D3 administration show cardioprotective effect reported by significant decrease (P >0.01) incTnI, Bcl2 and TAO as compared with DOX group, also show significant improvement (P >0.01) in cardiomyopathy histological lesions score. CONCLUSION: Conclusions: At their applied doses in the present study, vitamin D3 exerted a significant heart protective effect against cardiotoxicity induced by doxorubicin in rats probably by intrusive with Oxidative-stress, inflammatory response in addition to apoptotic pathway.