Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil.

Nandi, Sourav Kumar; Roychowdhury, Tanaya; Chattopadhyay, Samit; Basu, Sudarshana; Chatterjee, Krishti; Choudhury, Pritha; Banerjee, Nirmalya; Saha, Prosenjit; Mukhopadhyay, Soma; Mukhopadhyay, Ashis; Bhattacharya, Rittwika

Nandi, Sourav Kumar; Roychowdhury, Tanaya; Chattopadhyay, Samit; Basu, Sudarshana; Chatterjee, Krishti; Choudhury, Pritha; Banerjee, Nirmalya; Saha, Prosenjit; Mukhopadhyay, Soma; Mukhopadhyay, Ashis; Bhattacharya, Rittwika.

Afiliação

Nandi SK; Department of Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata 700094, India.
Roychowdhury T; Cancer Biology and Inflammatory Disorder Division, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata 700032, India.
Chattopadhyay S; Cancer Biology and Inflammatory Disorder Division, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata 700032, India; Department of Biological Sciences, BITS Pilani, K K Birla Goa Campus, India.
Basu S; Department of Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata 700094, India.
Chatterjee K; Department of Pathology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata 700094, India.
Choudhury P; Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, Shyamaprasad Mukherjee Rd, Kolkata, West Bengal 700026, India.
Banerjee N; Department of Pathology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata 700094, India.
Saha P; Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, Shyamaprasad Mukherjee Rd, Kolkata, West Bengal 700026, India.
Mukhopadhyay S; Department of Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata 700094, India. Electronic address: admin@nscri.in.
Mukhopadhyay A; Department of Haematooncology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata 700094, India.
Bhattacharya R; Department of Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata 700094, India. Electronic address: rittwika@nscri.in.

Toxicol Appl Pharmacol ; 437: 115887, 2022 02 15.

Article em En | MEDLINE | ID: mdl-35063459

Assuntos

Neoplasias da Mama/tratamento farmacológico; Receptores de Hialuronatos/metabolismo; Quempferóis/farmacologia; Proteína Homeobox Nanog/metabolismo; Verapamil/farmacologia; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo; Antineoplásicos/administração & dosagem; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Desoxicitidina/análogos & derivados; Desoxicitidina/farmacologia; Resistencia a Medicamentos Antineoplásicos; Sinergismo Farmacológico; Feminino; Regulação da Expressão Gênica/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Receptores de Hialuronatos/genética; Quempferóis/administração & dosagem; Proteína Homeobox Nanog/genética; Células-Tronco Neoplásicas/efeitos dos fármacos; Verapamil/administração & dosagem; Gencitabina

Palavras-chave

Anti-cancer; Breast cancer stem cells; Induced pluripotent stem cell; Kaempferol; Multidrug resistance; Neoadjuvant therapy; Synergism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Verapamil / Receptores de Hialuronatos / Quempferóis / Proteína Homeobox Nanog Tipo de estudo: Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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