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A programmable and skin temperature-activated electromechanical synergistic dressing for effective wound healing.
Yao, Guang; Mo, Xiaoyi; Yin, Chenhui; Lou, Wenhao; Wang, Qian; Huang, Sirong; Mao, Linna; Chen, Sihong; Zhao, Kangning; Pan, Taisong; Huang, Lin; Lin, Yuan.
Afiliação
  • Yao G; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Mo X; State Key Laboratory of Electronic Thin films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Yin C; Medico-Engineering Cooperation on Applied Medicine Research Center, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Lou W; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Wang Q; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Huang S; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Mao L; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Chen S; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Zhao K; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Pan T; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  • Huang L; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, Hubei, China.
  • Lin Y; School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
Sci Adv ; 8(4): eabl8379, 2022 Jan 28.
Article em En | MEDLINE | ID: mdl-35080981
ABSTRACT
Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature-activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. This strategy is successfully demonstrated on rats to achieve effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively, with a statistically significant over 50% improvement in wound closure rate versus the blank control group. The optimally designed electromechanical synergistic stimulation could regulate the wound microenvironment to accelerate healing metabolism, promote wound closure, and inhibit infection. This work provided an effective wound healing strategy in the context of a programmable temperature-responsive, battery-free electromechanical synergistic biomedical device.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article