Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib.

Lim, Chaemin; Dismuke, Taylor; Malawsky, Daniel; Ramsey, Jacob D; Hwang, Duhyeong; Godfrey, Virginia L; Kabanov, Alexander V; Gershon, Timothy R; Sokolsky-Papkov, Marina

Lim, Chaemin; Dismuke, Taylor; Malawsky, Daniel; Ramsey, Jacob D; Hwang, Duhyeong; Godfrey, Virginia L; Kabanov, Alexander V; Gershon, Timothy R; Sokolsky-Papkov, Marina.

Afiliação

Lim C; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Dismuke T; Department of Neurology, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Malawsky D; Department of Pathology, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ramsey JD; Department of Neurology, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Hwang D; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK.
Godfrey VL; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kabanov AV; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gershon TR; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sokolsky-Papkov M; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Sci Adv ; 8(4): eabl5838, 2022 Jan 28.

Article em En | MEDLINE | ID: mdl-35080986

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article