Dupuytren Cords Do Not Undergo Significant Histopathological Change After Collagenase Clostridium Histolyticum Injection.
Hand (N Y)
; 18(6): 912-917, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-35081825
ABSTRACT
Background:
Dupuytren disease creates thickened cords of the palmar fascia, leading to progressive flexion contractures that severely hinder hand function. Collagenase clostridium histolyticum (CCH) injection is a common, minimally invasive alternative to surgical excision of these cords. The impact of CCH injection on the histological architecture of Dupuytren cords has not been studied extensively.Methods:
A series of 10 CCH-injected cords were evaluated histologically. Cellularity, architecture, and connective tissue organization were compared against uninjected Dupuytren cords and normal palmar fascia.Results:
No significant histopathological differences between CCH-injected and CCH-uninjected cords were identified.Conclusions:
Dupuytren cords do not demonstrate histological changes with prior exposure to CCH.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colagenase Microbiana
/
Contratura de Dupuytren
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article