Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury.

Noda, Takumi; Kato, Ryuji; Hattori, Tomoko; Furukawa, Yuichi; Ijiri, Yoshio; Tanaka, Kazuhiko

Noda, Takumi; Kato, Ryuji; Hattori, Tomoko; Furukawa, Yuichi; Ijiri, Yoshio; Tanaka, Kazuhiko.

Afiliação

Noda T; Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka Medical and Pharmaceutical University, Nasahara, Takatsuki, Osaka, Japan.
Kato R; Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka Medical and Pharmaceutical University, Nasahara, Takatsuki, Osaka, Japan.
Hattori T; Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka Medical and Pharmaceutical University, Nasahara, Takatsuki, Osaka, Japan.
Furukawa Y; Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka Medical and Pharmaceutical University, Nasahara, Takatsuki, Osaka, Japan.
Ijiri Y; Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka Medical and Pharmaceutical University, Nasahara, Takatsuki, Osaka, Japan. Electronic address: yoshio.ijiri@ompu.ac.jp.
Tanaka K; Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka Medical and Pharmaceutical University, Nasahara, Takatsuki, Osaka, Japan; Kidney Center, Shirasagi Hospital, Kumata, Higashisumiyoshi-ku, Osaka, Japan.

Life Sci ; 294: 120351, 2022 Apr 01.

Article em En | MEDLINE | ID: mdl-35092733

Assuntos

Acetaminofen/toxicidade; Biomarcadores/metabolismo; Caspase 8/metabolismo; Caspase 9/metabolismo; Doença Hepática Induzida por Substâncias e Drogas/patologia; Hepatócitos/patologia; Estresse Oxidativo; Analgésicos não Narcóticos/toxicidade; Animais; Caspase 8/genética; Caspase 9/genética; Doença Hepática Induzida por Substâncias e Drogas/etiologia; Doença Hepática Induzida por Substâncias e Drogas/metabolismo; Glutationa; Hepatócitos/efeitos dos fármacos; Hepatócitos/metabolismo; Humanos; Inflamassomos/imunologia; Inflamassomos/metabolismo; Masculino; Ratos

Palavras-chave

Acetaminophen induced liver injury; Damage associated molecular patterns; Idiosyncratic drug induced liver injury; Inflammasome; Toxic drug induced liver injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Estresse Oxidativo / Hepatócitos / Caspase 8 / Caspase 9 / Doença Hepática Induzida por Substâncias e Drogas / Acetaminofen Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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