A genome-wide association study for varicose veins.
Phlebology
; 37(4): 267-278, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-35099328
ABSTRACT
BACKGROUND:
The aim was to compare the genetic information of varicose vein patients with that of a healthy population attempting to identify certain significant genetic associations.METHOD:
Patients' clinical characteristics and demographics were collected, and their genetic samples were examined. The results were compared to the genetic information of one thousand sex-matched healthy controls from Taiwan Biobank database. The Clinical-Etiology-Anatomy-Pathophysiology classification was applied for further subgroup analysis.RESULTS:
After comparison of genetic information of ninety-six patients to that of healthy controls, two significant single nucleotide polymorphisms (SNPs) were identified. One was in DPYSL2 gene, and the other was in VSTM2L gene. A further comparison between C2-3 patient subgroup and C4-6 subgroup identified another four significant SNPs, which were located in ZNF664-FAM101A, PHF2, ACOT11, and TOM1L1 genes.CONCLUSION:
Our preliminary result identified six significant SNPs located in six different genes. All of them and their genetic products may warrant further investigations.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Varizes
/
Estudo de Associação Genômica Ampla
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article