Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.
Acta Crystallogr F Struct Biol Commun
; 78(Pt 2): 45-51, 2022 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-35102892
ABSTRACT
Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Burkholderia pseudomallei
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Betaína-Aldeído Desidrogenase
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article