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Photoswitchable inhibitors of human ß-glucocerebrosidase.
Davighi, Maria Giulia; Clemente, Francesca; Matassini, Camilla; Cardona, Francesca; Nielsen, Mogens Brøndsted; Goti, Andrea; Morrone, Amelia; Paoli, Paolo; Cacciarini, Martina.
Afiliação
  • Davighi MG; Department of Chemistry "U. Schiff", University of Florence, via della Lastruccia 3-13, 50019 Sesto F.no (FI), Italy. martina.cacciarini@unifi.it.
  • Clemente F; Department of Chemistry "U. Schiff", University of Florence, via della Lastruccia 3-13, 50019 Sesto F.no (FI), Italy. martina.cacciarini@unifi.it.
  • Matassini C; Department of Chemistry "U. Schiff", University of Florence, via della Lastruccia 3-13, 50019 Sesto F.no (FI), Italy. martina.cacciarini@unifi.it.
  • Cardona F; Department of Chemistry "U. Schiff", University of Florence, via della Lastruccia 3-13, 50019 Sesto F.no (FI), Italy. martina.cacciarini@unifi.it.
  • Nielsen MB; Associated with LENS, via N. Carrara 1, 50019 Sesto F.no (FI), Italy.
  • Goti A; Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark.
  • Morrone A; Department of Chemistry "U. Schiff", University of Florence, via della Lastruccia 3-13, 50019 Sesto F.no (FI), Italy. martina.cacciarini@unifi.it.
  • Paoli P; Associated with LENS, via N. Carrara 1, 50019 Sesto F.no (FI), Italy.
  • Cacciarini M; Paediatric Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital, and Department of Neurosciences, Pharmacology and Child Health. University of Florence, Viale Pieraccini 24, 50139 Firenze, Italy.
Org Biomol Chem ; 20(8): 1637-1641, 2022 02 23.
Article em En | MEDLINE | ID: mdl-35107482
ABSTRACT
Light-switchable inhibitors of the enzyme ß-glucocerebrosidase (GCase) have been developed by anchoring a specific azasugar to a dihydroazulene or an azobenzene responsive moiety. Their inhibitory effect towards human GCase, before and after irradiation are reported, and the effect on thermal denaturation of recombinant GCase and cytotoxicity were studied on selected candidates.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Azo / Inibidores Enzimáticos / Azulenos / Glucosilceramidase Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Azo / Inibidores Enzimáticos / Azulenos / Glucosilceramidase Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article