Photoswitchable inhibitors of human ß-glucocerebrosidase.
Org Biomol Chem
; 20(8): 1637-1641, 2022 02 23.
Article
em En
| MEDLINE
| ID: mdl-35107482
ABSTRACT
Light-switchable inhibitors of the enzyme ß-glucocerebrosidase (GCase) have been developed by anchoring a specific azasugar to a dihydroazulene or an azobenzene responsive moiety. Their inhibitory effect towards human GCase, before and after irradiation are reported, and the effect on thermal denaturation of recombinant GCase and cytotoxicity were studied on selected candidates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Azo
/
Inibidores Enzimáticos
/
Azulenos
/
Glucosilceramidase
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article