Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia.
Intern Med
; 61(16): 2441-2448, 2022 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-35110476
ABSTRACT
A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acloridria
/
Neoplasias Gástricas
/
Tumores Neuroendócrinos
/
Gastrite Atrófica
Tipo de estudo:
Etiology_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article