Heat shock induces premature transcript termination and reconfigures the human transcriptome.

Cugusi, Simona; Mitter, Richard; Kelly, Gavin P; Walker, Jane; Han, Zhong; Pisano, Paola; Wierer, Michael; Stewart, Aengus; Svejstrup, Jesper Q

Cugusi, Simona; Mitter, Richard; Kelly, Gavin P; Walker, Jane; Han, Zhong; Pisano, Paola; Wierer, Michael; Stewart, Aengus; Svejstrup, Jesper Q.

Afiliação

Cugusi S; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Mitter R; Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Kelly GP; Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Walker J; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Han Z; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen N, Denmark.
Pisano P; Proteomics Research Infrastructure, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen N, Denmark.
Wierer M; Proteomics Research Infrastructure, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen N, Denmark.
Stewart A; Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Svejstrup JQ; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: jsvejstrup@sund.ku.dk.

Mol Cell ; 82(8): 1573-1588.e10, 2022 04 21.

Article em En | MEDLINE | ID: mdl-35114099

Assuntos

Poliadenilação; Transcriptoma; Resposta ao Choque Térmico/genética; Humanos; RNA Polimerase II/genética; RNA Polimerase II/metabolismo; RNA Mensageiro/genética

Palavras-chave

CDK9; CPSF3; SCAF4; SCAF8; TT-seq; U1 snRNA; alternative polyadenylation; cryptic polyadenylation sites; elongation; heat shock; pTEFb; pause release; premature termination; telescripting; transcriptional repression

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliadenilação / Transcriptoma Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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