Regulation of two-pore-domain potassium TREK channels and their involvement in pain perception and migraine.
Neurosci Lett
; 773: 136494, 2022 03 16.
Article
em En
| MEDLINE
| ID: mdl-35114333
ABSTRACT
The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that transduce noxious stimuli into pain. Among these ion channels, TREK1, TREK2 and TRAAK from the TREK subfamily of the Two-Pore-Domain potassium (K2P) channels, are hyperpolarizing channels that render neurons hypoexcitable. They are regulated by diverse physical and chemical stimuli as well as neurotransmitters through G-protein coupled receptor activation. Here, we review the molecular mechanisms underlying these regulations and their functional relevance in pain and migraine induction.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Potássio de Domínios Poros em Tandem
/
Transtornos de Enxaqueca
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article