Inflammatory fibroblasts make rectal cancer resistant to radiation therapy.

Mhaidly, Rana; Mechta-Grigoriou, Fatima

Mhaidly, Rana; Mechta-Grigoriou, Fatima.

Afiliação

Mhaidly R; Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, 26, Rue d'Ulm, 75248 Paris, France; Inserm, U830, 26, Rue d'Ulm, 75005 Paris, France.
Mechta-Grigoriou F; Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, 26, Rue d'Ulm, 75248 Paris, France; Inserm, U830, 26, Rue d'Ulm, 75005 Paris, France. Electronic address: fatima.mechta-grigoriou@curie.fr.

Cancer Cell ; 40(2): 122-124, 2022 02 14.

Article em En | MEDLINE | ID: mdl-35120597

ABSTRACT

ABSTRACT

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Still, the molecular mechanisms that drive CRC therapy resistance are incompletely understood. In this issue of Cancer Cell, Nicolas et al. combine several approaches to unravel a critical role for inflammatory cancer-associated fibroblasts (iCAFs) and interleukin 1α (IL1α) signaling in radiotherapy resistance.

Assuntos

Fibroblastos Associados a Câncer; Neoplasias Retais; Fibroblastos; Humanos; Neoplasias Retais/radioterapia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Fibroblastos Associados a Câncer Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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