Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA.
RSC Chem Biol
; 3(1): 32-36, 2022 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-35128406
ABSTRACT
Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-κB subunit RELA has been implicated in several pathological conditions. Here we report the discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to inhibit TNFα-induced nuclear translocation. This is a previously unexplored strategy to inhibit TNFα-induced NF-κB activation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article