Emodin-8-O-ß-D-glucopyranoside, a natural hydroxyanthraquinone glycoside from plant, suppresses cancer cell proliferation via p21-CDKs-Rb axis.

Li, Yiqun; Li, Kaiming; Zhao, Yan; Li, Yong; Li, Dengke; Shen, Liangliang; Wang, Qing; Yang, Hsin-Sheng; Sun, Zhenxiao

Li, Yiqun; Li, Kaiming; Zhao, Yan; Li, Yong; Li, Dengke; Shen, Liangliang; Wang, Qing; Yang, Hsin-Sheng; Sun, Zhenxiao.

Afiliação

Li Y; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Li K; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Zhao Y; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Li Y; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Li D; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Shen L; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Wang Q; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA.
Yang HS; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA. Electronic address: hyang3@uky.edu.
Sun Z; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China. Electronic address: sunzxcn@hotmail.com.

Toxicol Appl Pharmacol ; 438: 115909, 2022 03 01.

Article em En | MEDLINE | ID: mdl-35134436

Assuntos

Antraquinonas/farmacologia; Proliferação de Células/efeitos dos fármacos; Inibidor de Quinase Dependente de Ciclina p21/metabolismo; Quinases Ciclina-Dependentes/metabolismo; Emodina/farmacologia; Glicosídeos/farmacologia; Proteína do Retinoblastoma/metabolismo; Animais; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Células HCT116; Células HT29; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Fosforilação/efeitos dos fármacos; Retinoblastoma/tratamento farmacológico; Retinoblastoma/metabolismo; Transdução de Sinais/efeitos dos fármacos; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

CDK1/2; Emodin-8-O-ß-D-glucopyranoside; Rb phosphorylation; Tumor growth inhibition; p21

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína do Retinoblastoma / Antraquinonas / Emodina / Quinases Ciclina-Dependentes / Proliferação de Células / Inibidor de Quinase Dependente de Ciclina p21 / Glicosídeos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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