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Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome: an international cross-sectional study.
Verploegen, Maartje F A; Vargas-Poussou, Rosa; Walsh, Stephen B; Alpay, Harika; Amouzegar, Atefeh; Ariceta, Gema; Atmis, Bahriye; Bacchetta, Justine; Bárány, Peter; Baron, Stéphanie; Bayrakci, Umut Selda; Belge, Hendrica; Besouw, Martine; Blanchard, Anne; Bökenkamp, Arend; Boyer, Olivia; Burgmaier, Kathrin; Calò, Lorenzo A; Decramer, Stéphane; Devuyst, Olivier; van Dyck, Maria; Ferraro, Pietro Manuel; Fila, Marc; Francisco, Telma; Ghiggeri, Gian Marco; Gondra, Leire; Guarino, Stefano; Hooman, Nakysa; Hoorn, Ewout J; Houillier, Pascal; Kamperis, Konstantinos; Kari, Jameela A; Konrad, Martin; Levtchenko, Elena; Lucchetti, Laura; Lugani, Francesca; Marzuillo, Pierluigi; Mohidin, Barian; Neuhaus, Thomas J; Osman, Abdaldafae; Papizh, Svetlana; Perelló, Manel; Rookmaaker, Maarten B; Conti, Valerie Said; Santos, Fernando; Sawaf, Ghalia; Serdaroglu, Erkin; Szczepanska, Maria; Taroni, Francesca; Topaloglu, Rezan.
Afiliação
  • Verploegen MFA; Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Vargas-Poussou R; Department of Genetics, Centre de Références MARHEA, Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris, Paris, France.
  • Walsh SB; Department of Renal Medicine, University College London, London, UK.
  • Alpay H; Division of Paediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
  • Amouzegar A; Division of Nephrology, Department of Medicine, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran.
  • Ariceta G; Paediatric Nephrology Department, University Hospital Vall d'Hebron, Barcelona, Spain.
  • Atmis B; Department of Paediatric Nephrology, Cukurova University Faculty of Medicine, Adana, Turkey.
  • Bacchetta J; Department of Paediatric Nephrology, Rheumatology and Dermatology, Reference Centre for Rare Renal Diseases, Reference Centre for Rare Diseases of Calcium and Phosphate Metabolism. University Children's Hospital, Lyon, France.
  • Bárány P; Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
  • Baron S; Department of Physiology, Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris, Paris, France.
  • Bayrakci US; Department of Paediatric Nephrology, Ankara City Hospital, Üniversiteler Mahallesi Bilkent Caddesi, Çankaya/Ankara, Turkey.
  • Belge H; Center for Human Genetics, Institute of Pathology and Genetics, Gosselies, Belgium.
  • Besouw M; Department of Paediatric Nephrology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
  • Blanchard A; Clinical Research Centre 1418, Centre de Références MARHEA, Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris, Paris, France.
  • Bökenkamp A; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
  • Boyer O; Department of Paediatric Nephrology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Burgmaier K; Department of Paediatric Nephrology, Necker Hospital, APHP, MARHEA, Imagine Institute, Paris University, Paris, France.
  • Calò LA; Faculty of Medicine, University Hospital of Cologne, Children's and Adolescents' Hospital, Paediatric Nephrology, University of Cologne, Cologne, Germany.
  • Decramer S; Department of Medicine (DIMED), Nephrology, Dialysis, Transplantation, University of Padova, Padova, Italy.
  • Devuyst O; Department of Paediatric Nephrology. Centre de Références SORARE, Toulouse University Hospital, Toulouse, France.
  • van Dyck M; Division of Nephrology, UCLouvain Medical School, Brussels, Belgium; Institute of Physiology, Mechanism of Inherited Kidney Disorders Group, University of Zurich, Zurich, Switzerland.
  • Ferraro PM; Department of Paediatric Nephrology, University Hospital Leuven, Leuven, Belgium.
  • Fila M; U.O.S. Terapia Conservativa della Malattia Renale Cronica, U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Francisco T; Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Ghiggeri GM; Pediatric Nephrology, CHU Arnaud de Villeneuve, Montpellier University Hospital, Montpellier, France.
  • Gondra L; Department of Paediatric Nephrology, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.
  • Guarino S; Division of Nephrology, Dialysis and Transplantation, Istituto Giannina Gaslini, IRCCS, Genoa, Italy.
  • Hooman N; Pediatric Nephrology Department, Cruces University Hospital, Barakaldo, Spain; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain; Paediatric Department, University of the Basque Country UPV/EHU, Leioa, Spain.
  • Hoorn EJ; Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.
  • Houillier P; Ali-Asghar Clinical Research Development Centre, Iran University of Medical Sciences, Tehran, Iran.
  • Kamperis K; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
  • Kari JA; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
  • Konrad M; Department of Physiology, Centre de Références MARHEA, Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris, Paris, France.
  • Levtchenko E; Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
  • Lucchetti L; Pediatric Nephrology Centre of Excellence and Paediatric Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
  • Lugani F; Department of General Paediatrics, Paediatric Nephrology, University Hospital Münster, Munster, Germany.
  • Marzuillo P; Department of Paediatric Nephrology & Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Mohidin B; Department of Paediatric Subspecialties, Division of Nephrology, Bambino Gesù Children's Hospital - IRCCS, Rome, Italy.
  • Neuhaus TJ; Division of Nephrology, Dialysis and Transplantation, Istituto Giannina Gaslini, IRCCS, Genoa, Italy.
  • Osman A; Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.
  • Papizh S; Department of Renal Medicine, University College London, London, UK.
  • Perelló M; Department of Paediatrics, Children's Hospital of Lucerne, Cantonal Hospital of Lucerne, Lucerne, Switzerland.
  • Rookmaaker MB; Paediatric Nephrology Unit, Great Ormond Street Hospital, London, UK.
  • Conti VS; Department of Hereditary and Acquired Kidney Diseases, Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University, Moscow, Russia.
  • Santos F; Nephrology Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Sawaf G; Department of Nephrology and Hypertension, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Serdaroglu E; Department of Paediatrics, Mater Dei Hospital Malta, Msida, Malta.
  • Szczepanska M; Department of Paediatrics, Asturias Central University Hospital, University of Oviedo, Oviedo, Spain.
  • Taroni F; Department of Paediatric Nephrology, Damascus Hospital, Damascus, Syria.
  • Topaloglu R; Department of Paediatric Nephrology, Dr Behçet Uz Children's Hospital, Izmir, Turkey.
Nephrol Dial Transplant ; 37(12): 2474-2486, 2022 11 23.
Article em En | MEDLINE | ID: mdl-35137195
BACKGROUND: Small cohort studies have reported high parathyroid hormone (PTH) levels in patients with Bartter syndrome and lower serum phosphate levels have anecdotally been reported in patients with Gitelman syndrome. In this cross-sectional study, we assessed PTH and phosphate homeostasis in a large cohort of patients with salt-losing tubulopathies. METHODS: Clinical and laboratory data of 589 patients with Bartter and Gitelman syndrome were provided by members of the European Rare Kidney Diseases Reference Network (ERKNet) and the European Society for Paediatric Nephrology (ESPN). RESULTS: A total of 285 patients with Bartter syndrome and 304 patients with Gitelman syndrome were included for analysis. Patients with Bartter syndrome type I and II had the highest median PTH level (7.5 pmol/L) and 56% had hyperparathyroidism (PTH >7.0 pmol/L). Serum calcium was slightly lower in Bartter syndrome type I and II patients with hyperparathyroidism (2.42 versus 2.49 mmol/L; P = .038) compared to those with normal PTH levels and correlated inversely with PTH (rs -0.253; P = .009). Serum phosphate and urinary phosphate excretion did not correlate with PTH. Overall, 22% of patients had low serum phosphate levels (phosphate-standard deviation score < -2), with the highest prevalence in patients with Bartter syndrome type III (32%). Serum phosphate correlated with tubular maximum reabsorption of phosphate/glomerular filtration rate (TmP/GFR) (rs 0.699; P < .001), suggesting renal phosphate wasting. CONCLUSIONS: Hyperparathyroidism is frequent in patients with Bartter syndrome type I and II. Low serum phosphate is observed in a significant number of patients with Bartter and Gitelman syndrome and appears associated with renal phosphate wasting.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Bartter / Síndrome de Gitelman / Hiperparatireoidismo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Bartter / Síndrome de Gitelman / Hiperparatireoidismo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article