Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma.
Metabolomics
; 18(2): 13, 2022 02 10.
Article
em En
| MEDLINE
| ID: mdl-35141784
ABSTRACT
BACKGROUND:
The paternal diet affects lipid metabolism in offspring for at least two generations through nutritional programming. However, we do not know how this is propagated to the offspring.OBJECTIVES:
We tested the hypothesis that the changes in lipid metabolism that are driven by paternal diet are propagated through spermatozoa and not seminal plasma.METHODS:
We applied an updated, purpose-built computational network analysis tool to characterise control of lipid metabolism systemically (Lipid Traffic Analysis v2.3) on a known mouse model of paternal nutritional programming.RESULTS:
The analysis showed that the two possible routes for programming effects, the sperm (genes) and seminal plasma (influence on the uterine environment), both have a distinct effect on the offspring's lipid metabolism. Further, the programming effects in offspring suggest that changes in lipid distribution are more important than alterations in lipid biosynthesis.CONCLUSIONS:
These results show how the uterine environment and genes both affect lipid metabolism in offspring, enhancing our understanding of the link between parental diet and metabolism in offspring.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sêmen
/
Metabolismo dos Lipídeos
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article