Y recombination arrest and degeneration in the absence of sexual dimorphism.
Science
; 375(6581): 663-666, 2022 02 11.
Article
em En
| MEDLINE
| ID: mdl-35143289
ABSTRACT
Current theory proposes that degenerated sex chromosomes-such as the mammalian Y-evolve through three steps:
(i) recombination arrest, linking male-beneficial alleles to the Y chromosome; (ii) Y degeneration, resulting from the inefficacy of selection in the absence of recombination; and (iii) dosage compensation, correcting the resulting low expression of X-linked genes in males. We investigate a model of sex chromosome evolution that incorporates the coevolution of cis and trans regulators of gene expression. We show that the early emergence of dosage compensation favors the maintenance of Y-linked inversions by creating sex-antagonistic regulatory effects. This is followed by degeneration of these nonrecombining inversions caused by regulatory divergence between the X and Y chromosomes. In contrast to current theory, the whole process occurs without any selective pressure related to sexual dimorphism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
/
Cromossomo Y
/
Regulação da Expressão Gênica
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Caracteres Sexuais
/
Evolução Molecular
/
Modelos Genéticos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article