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Glymphatic Dysfunction in Patients With End-Stage Renal Disease.
Heo, Chang Min; Lee, Won Ho; Park, Bong Soo; Lee, Yoo Jin; Park, Sihyung; Kim, Yang Wook; Lee, Dong Ah; Yoo, Byeong Cheol; Park, Kang Min.
Afiliação
  • Heo CM; Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
  • Lee WH; Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
  • Park BS; Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
  • Lee YJ; Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
  • Park S; Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
  • Kim YW; Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
  • Lee DA; Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
  • Yoo BC; Department of Clinical Research, DEEPNOID, Seoul, South Korea.
  • Park KM; Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Front Neurol ; 12: 809438, 2021.
Article em En | MEDLINE | ID: mdl-35145471
ABSTRACT

BACKGROUND:

We aimed to compare glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls and analyze the correlation between the glymphatic function and clinical characteristics using the diffusion tensor image analysis along with the perivascular space (DTI-ALPS) index.

METHODS:

We prospectively enrolled neurologically asymptomatic 49 patients with ESRD undergoing dialysis and 38 healthy controls. Diffusion tensor image was conducted using the same 3T scanner, and the DTI-ALPS index was calculated. We compared the DTI-ALPS index between the patients with ESRD and healthy controls. In addition, we conducted a correlation analysis between the clinical characteristics and DTI-ALPS index in patients with ESRD.

RESULTS:

There were significant differences in the DTI-ALPS index between patients with ESRD and healthy controls. The DTI-ALPS index in patients with ESRD was lower than that in healthy controls (1.460 vs. 1.632, p = 0.003). In addition, there was a significant positive correlation between the DTI-ALPS index and serum parathyroid hormone levels (r = 0.357, p = 0.011).

CONCLUSION:

We demonstrated glymphatic dysfunction in patients with ESRD, as revealed by the DTI-ALPS index. This study also reveals the feasibility of the DTI-ALPS method to determine glymphatic function in patients with ESRD, which could be used in future research studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article