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Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations.
Toyoda, Yu; Nakayama, Akiyoshi; Nakatochi, Masahiro; Kawamura, Yusuke; Nakaoka, Hirofumi; Yamamoto, Ken; Shimizu, Seiko; Ooyama, Hiroshi; Ooyama, Keiko; Shimizu, Toru; Nagase, Mitsuo; Hidaka, Yuji; Ichida, Kimiyoshi; Inoue, Ituro; Shinomiya, Nariyoshi; Matsuo, Hirotaka.
Afiliação
  • Toyoda Y; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
  • Nakayama A; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
  • Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Aichi, Japan.
  • Kawamura Y; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
  • Nakaoka H; Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Shizuoka, Japan; Department of Cancer Genome Research, Sasaki Institute, Sasaki Foundation, Tokyo, Japan.
  • Yamamoto K; Department of Medical Biochemistry, Kurume University School of Medicine, Fukuoka, Japan.
  • Shimizu S; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
  • Ooyama H; Ryougoku East Gate Clinic, Tokyo, Japan.
  • Ooyama K; Ryougoku East Gate Clinic, Tokyo, Japan.
  • Shimizu T; Midorigaoka Hospital, Osaka, Japan; Kyoto Industrial Health Association, Kyoto, Japan.
  • Nagase M; Nagase Clinic, Tokyo, Japan.
  • Hidaka Y; Akasaka Central Clinic, Tokyo, Japan.
  • Ichida K; Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan; Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan.
  • Inoue I; Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Shizuoka, Japan.
  • Shinomiya N; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
  • Matsuo H; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan. Electronic address: hmatsuo.ndmc@gmail.com.
Mol Genet Metab ; 136(3): 186-189, 2022 07.
Article em En | MEDLINE | ID: mdl-35148957
ABSTRACT
Despite progress in understanding of the genetic basis of gout, the precise factors affecting differences in gout susceptibility among different gout subtypes remain unclear. Using clinically diagnosed gout patients, we conducted a genome-wide meta-analysis of two distinct gout subtypes the renal overload type and the renal underexcretion type. We provide genetic evidence at a genome-wide level of significance that supports a positive association between ABCG2 dysfunction and acquisition of the renal overload type.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Gota Tipo de estudo: Systematic_reviews Limite: Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Gota Tipo de estudo: Systematic_reviews Limite: Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article