Risk Factors for Female Breast Cancer: A Population Cohort Study.

ABSTRACT

BACKGROUND: The incidence of female BC among the Eastern and Southeastern Asian populations has gradually increased in recent years. However, epidemiological studies on the relationship between a sedentary lifestyle and female BC are insufficient. In order to determine the association between this lifestyle and the incidence of female BC, we conducted a population-based cohort study on women in Taiwan. METHODS: We followed a prospective cohort of 5879 women aged 30 years and over enrolled in the 2001 National Health Interview Survey (NHIS), who developed female BC over a period of 72,453 person years, and we estimated the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) using the Cox proportional hazards model. RESULTS: RFs associated with female BC incidence included parity (adjusted HR = 0.63; 95% CI 0.44-0.91), body mass index (adjusted HR = 1.34; 95% CI 1.04-1.71), and ≥3 h/day spent sitting (adjusted HR = 1.89; 95% CI 1.08-3.32). The incidence of female BC in participants who sat for ≥3 h/day and consumed sugary drinks was 2.5 times greater than that in those who sat for <3 h/day and did not consume sugary drinks (adjusted HR = 2.51; 95% CI 1.01-6.23). CONCLUSIONS: The findings of this study indicate that sedentary behavior and sugary drink intake may increase the risk of developing female BC. These are modifiable RFs; therefore, a healthy lifestyle and diet can reduce the incidence of female BC.