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Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects.
Sun, Yuwen; Li, Manrui; Cao, Shuqiang; Xu, Yang; Wu, Peiyan; Xu, Shuting; Pan, Qian; Guo, Yadong; Ye, Yi; Wang, Zheng; Dai, Hao; Xie, Xiaoqi; Chen, Xiameng; Liang, Weibo.
Afiliação
  • Sun Y; West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Li M; Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Cao S; Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Xu Y; West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Wu P; West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Xu S; West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Pan Q; West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Guo Y; Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha 410013, China.
  • Ye Y; Department of Forensic Toxicological Analysis, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Wang Z; Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Dai H; Department of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Xie X; Department of West China Clinical Medicine, Sichuan University, Chengdu 610041, China.
  • Chen X; Department of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Liang W; Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Int J Mol Sci ; 23(3)2022 Feb 04.
Article em En | MEDLINE | ID: mdl-35163726
ABSTRACT
Optogenetics is emerging as an ideal method for controlling cellular activity. It overcomes some notable shortcomings of conventional methods in the elucidation of neural circuits, promotion of neuroregeneration, prevention of cell death and treatment of neurological disorders, although it is not without its own limitations. In this review, we narratively review the latest research on the improvement and existing challenges of optogenetics, with a particular focus on the field of brain injury, aiming at advancing optogenetics in the study of brain injury and collating the issues that remain. Finally, we review the most current examples of research, applying photostimulation in clinical treatment, and we explore the future prospects of these technologies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Doenças do Sistema Nervoso Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Doenças do Sistema Nervoso Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article