The Biological Fate of Pharmaceutical Excipient ß-Cyclodextrin: Pharmacokinetics, Tissue Distribution, Excretion, and Metabolism of ß-Cyclodextrin in Rats.

Mu, Kunqian; Jiang, Kaiwen; Wang, Yue; Zhao, Zihan; Cang, Song; Bi, Kaishun; Li, Qing; Liu, Ran

Mu, Kunqian; Jiang, Kaiwen; Wang, Yue; Zhao, Zihan; Cang, Song; Bi, Kaishun; Li, Qing; Liu, Ran.

Afiliação

Mu K; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Jiang K; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Wang Y; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Zhao Z; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Cang S; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Bi K; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Li Q; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Liu R; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.

Molecules ; 27(3)2022 Feb 08.

Article em En | MEDLINE | ID: mdl-35164401

Assuntos

beta-Ciclodextrinas/metabolismo; beta-Ciclodextrinas/farmacocinética; Animais; Cromatografia Líquida de Alta Pressão; Excipientes/metabolismo; Excipientes/farmacocinética; Masculino; Ratos; Ratos Wistar; Espectrometria de Massas em Tandem; Distribuição Tecidual

Palavras-chave

LC-MS/MS; excretion; metabolism; pharmacokinetics; tissue distribution; ß-cyclodextrin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Ciclodextrinas Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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