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A randomized, double-blind phase I clinical trial of two recombinant dimeric RBD COVID-19 vaccine candidates: Safety, reactogenicity and immunogenicity.
Pérez-Rodríguez, Sonia; de la Caridad Rodríguez-González, Meiby; Ochoa-Azze, Rolando; Climent-Ruiz, Yanet; Alberto González-Delgado, Carlos; Paredes-Moreno, Beatriz; Valenzuela-Silva, Carmen; Rodríguez-Noda, Laura; Perez-Nicado, Rocmira; González-Mugica, Raúl; Martínez-Pérez, Marisel; Sánchez-Ramírez, Belinda; Hernández-García, Tays; Díaz-Machado, Alina; Tamayo-Rodríguez, Maura; Martín-Trujillo, Alis; Rubino-Moreno, Jorman; Suárez-Batista, Anamary; Dubed-Echevarría, Marta; Teresa Pérez-Guevara, María; Amoroto-Roig, Mayté; Chappi-Estévez, Yanet; Bergado-Báez, Gretchen; Pi-Estopiñán, Franciscary; Chen, Guang-Wu; Valdés-Balbín, Yury; García-Rivera, Dagmar; Verez-Bencomo, Vicente.
Afiliação
  • Pérez-Rodríguez S; National Centre of Toxicology (CENATOX), 31 Ave. and 114 Street, Marianao, Havana, Cuba.
  • de la Caridad Rodríguez-González M; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • Ochoa-Azze R; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba. Electronic address: ochoa@finlay.edu.cu.
  • Climent-Ruiz Y; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • Alberto González-Delgado C; National Centre of Toxicology (CENATOX), 31 Ave. and 114 Street, Marianao, Havana, Cuba.
  • Paredes-Moreno B; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • Valenzuela-Silva C; Institute of Cybernetics, Mathematics and Physics. 15 Street N° 551 between C and D Streets, Vedado, Havana, Cuba.
  • Rodríguez-Noda L; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • Perez-Nicado R; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • González-Mugica R; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • Martínez-Pérez M; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • Sánchez-Ramírez B; Center of Molecular Immunology, 15(th) Ave. and 216 Street, Siboney, Playa, Havana, Cuba.
  • Hernández-García T; Center of Molecular Immunology, 15(th) Ave. and 216 Street, Siboney, Playa, Havana, Cuba.
  • Díaz-Machado A; National Centre of Toxicology (CENATOX), 31 Ave. and 114 Street, Marianao, Havana, Cuba.
  • Tamayo-Rodríguez M; National Centre of Toxicology (CENATOX), 31 Ave. and 114 Street, Marianao, Havana, Cuba.
  • Martín-Trujillo A; National Centre of Toxicology (CENATOX), 31 Ave. and 114 Street, Marianao, Havana, Cuba.
  • Rubino-Moreno J; National Centre of Toxicology (CENATOX), 31 Ave. and 114 Street, Marianao, Havana, Cuba.
  • Suárez-Batista A; Research Centre of Civil Defense, San José de las Lajas, Mayabeque, Cuba.
  • Dubed-Echevarría M; Research Centre of Civil Defense, San José de las Lajas, Mayabeque, Cuba.
  • Teresa Pérez-Guevara M; Research Centre of Civil Defense, San José de las Lajas, Mayabeque, Cuba.
  • Amoroto-Roig M; National Coordinating Centre of Clinical Trials, 5(th) Ave. between 60 and 62 Ave., Miramar, Playa, Havana, Cuba.
  • Chappi-Estévez Y; National Coordinating Centre of Clinical Trials, 5(th) Ave. between 60 and 62 Ave., Miramar, Playa, Havana, Cuba.
  • Bergado-Báez G; Center of Molecular Immunology, 15(th) Ave. and 216 Street, Siboney, Playa, Havana, Cuba.
  • Pi-Estopiñán F; Center of Molecular Immunology, 15(th) Ave. and 216 Street, Siboney, Playa, Havana, Cuba.
  • Chen GW; Chengdu Olisynn Biotech. Co. Ltd., and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Valdés-Balbín Y; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • García-Rivera D; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
  • Verez-Bencomo V; Finlay Vaccine Institute. 21(st) Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.
Vaccine ; 40(13): 2068-2075, 2022 03 18.
Article em En | MEDLINE | ID: mdl-35164986

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Tipo de estudo: Clinical_trials Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Tipo de estudo: Clinical_trials Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article