NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis.

Hui, Jeremy B; Silva, Jose Cesar Hernandez; Pelaez, Mari Carmen; Sévigny, Myriam; Venkatasubramani, Janani Priya; Plumereau, Quentin; Chahine, Mohamed; Proulx, Christophe D; Sephton, Chantelle F; Dutchak, Paul A

Hui, Jeremy B; Silva, Jose Cesar Hernandez; Pelaez, Mari Carmen; Sévigny, Myriam; Venkatasubramani, Janani Priya; Plumereau, Quentin; Chahine, Mohamed; Proulx, Christophe D; Sephton, Chantelle F; Dutchak, Paul A.

Afiliação

Hui JB; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Silva JCH; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Pelaez MC; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Sévigny M; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Venkatasubramani JP; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Plumereau Q; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Chahine M; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Proulx CD; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Sephton CF; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada.
Dutchak PA; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec G1J 2G3, Canada paul.dutchak.1@ulaval.ca.

eNeuro ; 9(2)2022.

Article em En | MEDLINE | ID: mdl-35165201

Assuntos

Proteínas de Membrana Transportadoras; Proteínas Supressoras de Tumor; Aminoácidos; Animais; Encéfalo/metabolismo; Homeostase; Mamíferos/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Proteínas de Membrana Transportadoras/metabolismo; Camundongos; Canal de Sódio Disparado por Voltagem NAV1.1/metabolismo; Nitrogênio/metabolismo; Canais de Sódio/metabolismo; Proteínas Supressoras de Tumor/química; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo

Palavras-chave

GATOR1; NPRL2; epilepsy; mTORC1; neurometabolism; sodium channels

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Proteínas Supressoras de Tumor Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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