Your browser doesn't support javascript.
loading
Activating Human Adipose Tissue with the ß3-Adrenergic Agonist Mirabegron.
Chen, Kong Y; Brychta, Robert J; Israni, Nikita S; Jiang, Alex; Lea, Hannah J; Lentz, Taylor N; Pierce, Anne E; Cypess, Aaron M.
Afiliação
  • Chen KY; Diabetes, Endocrinology, and Obesity Branch, Intramural Research Program, National Institute of Diabetes, Bethesda, MD, USA. kong.chen@nih.gov.
  • Brychta RJ; Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. kong.chen@nih.gov.
  • Israni NS; Diabetes, Endocrinology, and Obesity Branch, Intramural Research Program, National Institute of Diabetes, Bethesda, MD, USA.
  • Jiang A; Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Lea HJ; Diabetes, Endocrinology, and Obesity Branch, Intramural Research Program, National Institute of Diabetes, Bethesda, MD, USA.
  • Lentz TN; Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Pierce AE; Diabetes, Endocrinology, and Obesity Branch, Intramural Research Program, National Institute of Diabetes, Bethesda, MD, USA.
  • Cypess AM; Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Methods Mol Biol ; 2448: 83-96, 2022.
Article em En | MEDLINE | ID: mdl-35167091
ABSTRACT
An appealing strategy for treatment of metabolic disease in humans is activation of brown adipose tissue (BAT), a thermogenic organ best visualized through 18F-FDG PET/CT. BAT has been activated to varying degrees by mild cold exposure. However, this approach can cause undesirable stress, and there remains no consensus protocol. Here, we describe standardized methods for both acute and chronic activation of BAT using the orally administered ß3-adrenergic receptor (AR) agonist, mirabegron. Acute pharmacological stimulation has enabled quantification of whole-body BAT volume and metabolic activity using PET/CT imaging, and chronic stimulation increases these properties of BAT over time.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Acetanilidas Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Acetanilidas Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article