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The Antarctic Weddell seal genome reveals evidence of selection on cardiovascular phenotype and lipid handling.
Noh, Hyun Ji; Turner-Maier, Jason; Schulberg, S Anne; Fitzgerald, Michael L; Johnson, Jeremy; Allen, Kaitlin N; Hückstädt, Luis A; Batten, Annabelle J; Alfoldi, Jessica; Costa, Daniel P; Karlsson, Elinor K; Zapol, Warren M; Buys, Emmanuel S; Lindblad-Toh, Kerstin; Hindle, Allyson G.
Afiliação
  • Noh HJ; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
  • Turner-Maier J; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
  • Schulberg SA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Fitzgerald ML; Lipid Metabolism Unit, Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Johnson J; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
  • Allen KN; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Hückstädt LA; Institute of Marine Sciences, Department of Ecology and Evolutionary Biology, University of California Santa Cruz, 130 McAllister Way, Santa Cruz, CA, 95060, USA.
  • Batten AJ; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Alfoldi J; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
  • Costa DP; Institute of Marine Sciences, Department of Ecology and Evolutionary Biology, University of California Santa Cruz, 130 McAllister Way, Santa Cruz, CA, 95060, USA.
  • Karlsson EK; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
  • Zapol WM; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.
  • Buys ES; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Lindblad-Toh K; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
  • Hindle AG; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Commun Biol ; 5(1): 140, 2022 02 17.
Article em En | MEDLINE | ID: mdl-35177770
ABSTRACT
The Weddell seal (Leptonychotes weddellii) thrives in its extreme Antarctic environment. We generated the Weddell seal genome assembly and a high-quality annotation to investigate genome-wide evolutionary pressures that underlie its phenotype and to study genes implicated in hypoxia tolerance and a lipid-based metabolism. Genome-wide analyses included gene family expansion/contraction, positive selection, and diverged sequence (acceleration) compared to other placental mammals, identifying selection in coding and non-coding sequence in five pathways that may shape cardiovascular phenotype. Lipid metabolism as well as hypoxia genes contained more accelerated regions in the Weddell seal compared to genomic background. Top-significant genes were SUMO2 and EP300; both regulate hypoxia inducible factor signaling. Liver expression of four genes with the strongest acceleration signals differ between Weddell seals and a terrestrial mammal, sheep. We also report a high-density lipoprotein-like particle in Weddell seal serum not present in other mammals, including the shallow-diving harbor seal.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma / Focas Verdadeiras / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma / Focas Verdadeiras / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article