Incretin Hypersecretion in Gestational Diabetes Mellitus.
J Clin Endocrinol Metab
; 107(6): e2425-e2430, 2022 05 17.
Article
em En
| MEDLINE
| ID: mdl-35180296
ABSTRACT
CONTEXT Incretins are crucial stimulators of insulin secretion following food intake. Data on incretin secretion and action during pregnancy are sparse. OBJECTIVE:
The aim of the study was to investigate the incretin response during an oral glucose tolerance test (OGTT) in pregnant women with and without gestational diabetes mellitus (GDM).DESIGN:
We analyzed data from the ongoing observational PREG study (NCT04270578).SETTING:
The study was conducted at the University Hospital Tübingen.PARTICIPANTS:
We examined 167 women (33 with GDM) during gestational week 27â ±â 2.2. INTERVENTION Subjects underwent 5-point OGTT with a 75-g glucose load. MAIN OUTCOMEMEASURES:
We assessed insulin secretion and levels of total glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), glicentin, and glucagon during OGTT. Linear regression was used to analyze the relation of GLP-1 and glucose with insulin secretion and the association of incretin levels on birth outcome.RESULTS:
Insulin secretion was significantly lower in women with GDM (Pâ <â 0.001). Postload GLP-1 and GIP were ~20% higher in women with GDM (all Pâ <â 0.05) independent of age, body mass index, and gestational age. GLP-1 increase was associated with insulin secretion only in GDM, but not in normal glucose tolerance. Postprandial GLP-1 levels were negatively associated with birth weight.CONCLUSIONS:
The more pronounced GLP-1 increase in women with GDM could be part of a compensatory mechanism counteracting GLP-1 resistance. Higher GLP-1 levels might be protective against fetal overgrowth.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Gestacional
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article