EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.

Zhou, Yeqiao; Petrovic, Jelena; Zhao, Jingru; Zhang, Wu; Bigdeli, Ashkan; Zhang, Zhen; Berger, Shelley L; Pear, Warren S; Faryabi, Robert B

Zhou, Yeqiao; Petrovic, Jelena; Zhao, Jingru; Zhang, Wu; Bigdeli, Ashkan; Zhang, Zhen; Berger, Shelley L; Pear, Warren S; Faryabi, Robert B.

Afiliação

Zhou Y; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Petrovic J; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Zhao J; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Zhang W; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Bigdeli A; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Zhang Z; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Berger SL; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Pear WS; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Faryabi RB; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University

Mol Cell ; 82(5): 1003-1020.e15, 2022 03 03.

Article em En | MEDLINE | ID: mdl-35182476

Assuntos

Cromatina; Leucemia-Linfoma Linfoblástico de Células T Precursoras; Cromatina/genética; Reposicionamento de Medicamentos; Humanos; Leucemia-Linfoma Linfoblástico de Células T Precursoras/tratamento farmacológico; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Linfócitos T/metabolismo; Transativadores/genética; Transativadores/metabolismo; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo

Palavras-chave

EBF1; T cell leukemia; TCF1; chromatin folding; drug resistance; epigenetic adaptation; genome topology; lineage-determining transcription factors; pioneer transcription factors; targeted therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Leucemia-Linfoma Linfoblástico de Células T Precursoras Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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