Generation of Functionalized Azepinone Derivatives via a (4 + 3)-Cycloaddition of Vinyl Ketenes and α-Imino Carbenes Derived from N-Sulfonyl-triazoles.
J Org Chem
; 87(5): 3825-3833, 2022 03 04.
Article
em En
| MEDLINE
| ID: mdl-35188763
ABSTRACT
An intermolecular RhII-catalyzed, formal (4 + 3)-cycloaddition between vinyl ketenes and N-sulfonyl-1,2,3-triazoles for the construction of azepinone products is described. Employing vinyl ketenes as a 1,4-dipolar surrogate, instead of the more commonly used dienyl moieties, allows for the intermolecular and selective formation of azepinone products over a potential (3 + 2)-cycloadduct under mild reaction conditions allows for the generation of azepinone products in up to 98% yield.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ródio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article