Biocompatible surface functionalization architecture for a diamond quantum sensor.
Proc Natl Acad Sci U S A
; 119(8)2022 02 22.
Article
em En
| MEDLINE
| ID: mdl-35193961
ABSTRACT
Quantum metrology enables some of the most precise measurements. In the life sciences, diamond-based quantum sensing has led to a new class of biophysical sensors and diagnostic devices that are being investigated as a platform for cancer screening and ultrasensitive immunoassays. However, a broader application in the life sciences based on nanoscale NMR spectroscopy has been hampered by the need to interface highly sensitive quantum bit (qubit) sensors with their biological targets. Here, we demonstrate an approach that combines quantum engineering with single-molecule biophysics to immobilize individual proteins and DNA molecules on the surface of a bulk diamond crystal that hosts coherent nitrogen vacancy qubit sensors. Our thin (sub-5 nm) functionalization architecture provides precise control over the biomolecule adsorption density and results in near-surface qubit coherence approaching 100 µs. The developed architecture remains chemically stable under physiological conditions for over 5 d, making our technique compatible with most biophysical and biomedical applications.
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01-internacional
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MEDLINE
Assunto principal:
Técnicas Biossensoriais
/
Diamante
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Nanotecnologia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article