Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis.

Desi, Ng; Tong, Qing Yun; Teh, Velda; Chan, Jia Jia; Zhang, Bin; Tabatabaeian, Hossein; Tan, Hui Qing; Kapeli, Katannya; Jin, Wenhao; Lim, Chun You; Kwok, Zhi Hao; Tan, Hwee Tong; Wang, Shi; Siew, Bei-En; Lee, Kuok-Chung; Chong, Choon-Seng; Tan, Ker-Kan; Yang, Henry; Kappei, Dennis; Yeo, Gene W; Chung, Maxey Ching Ming; Tay, Yvonne

Desi, Ng; Tong, Qing Yun; Teh, Velda; Chan, Jia Jia; Zhang, Bin; Tabatabaeian, Hossein; Tan, Hui Qing; Kapeli, Katannya; Jin, Wenhao; Lim, Chun You; Kwok, Zhi Hao; Tan, Hwee Tong; Wang, Shi; Siew, Bei-En; Lee, Kuok-Chung; Chong, Choon-Seng; Tan, Ker-Kan; Yang, Henry; Kappei, Dennis; Yeo, Gene W; Chung, Maxey Ching Ming; Tay, Yvonne.

Afiliação

Desi N; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
Tong QY; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore.
Teh V; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
Chan JJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
Zhang B; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
Tabatabaeian H; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
Tan HQ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
Kapeli K; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
Jin W; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
Lim CY; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
Kwok ZH; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
Tan HT; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
Wang S; Division of Pulmonary and Critical Care, Boston University, Boston, MA, 02118, USA.
Siew BE; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore.
Lee KC; Department of Pathology, National University Health System, Singapore, Singapore.
Chong CS; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Tan KK; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.
Yang H; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Kappei D; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.
Yeo GW; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Chung MCM; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.
Tay Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

Cell Mol Life Sci ; 79(3): 147, 2022 Feb 23.

Article em En | MEDLINE | ID: mdl-35195778

Assuntos

Autoantígenos/metabolismo; Carcinogênese/metabolismo; Neoplasias Colorretais/metabolismo; Retroalimentação Fisiológica; Proteínas Proto-Oncogênicas c-myc/metabolismo; Ribonucleoproteínas/metabolismo; Regiões 3' não Traduzidas; Animais; Autoantígenos/genética; Carcinogênese/genética; Proliferação de Células/genética; Neoplasias Colorretais/genética; Neoplasias Colorretais/patologia; Regulação Neoplásica da Expressão Gênica; Células HCT116; Humanos; Camundongos; Oncogenes; Ribonucleoproteínas/genética; Transcriptoma/genética; Transfecção; Carga Tumoral/genética; Ensaios Antitumorais Modelo de Xenoenxerto; Antígeno SS-B

Palavras-chave

Cancer; LARP1; MYC; Post-transcriptional regulation; RNA-binding protein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / Autoantígenos / Neoplasias Colorretais / Proteínas Proto-Oncogênicas c-myc / Retroalimentação Fisiológica / Carcinogênese Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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